RAD140

$75 $69
RAD140 is an investigational selective androgen receptor modulator (SARM) developed by Radius Health, Inc. for potential use in hormone replacement therapy. It was licensed by Ellipses Pharmaceuticals

Performance

Strength Increase：

★★ ★★★

Muscle Gain：

★★ ★★★

Reduce Fat/Water：

★★★★★

Side Effects：

★★ ★★★

Sustained Effects：

★★ ★★★

SKU：

10mg/tablet × 100 tablets/bottle

Package：

tablet

Appearance：

oral

Dosage：

2-4 capsules per day

Cycle：

4–6 weeks


File:RAD140 structure.png

RAD140 Overview:

Also known as Testolone, RAD140 is an orally bioavailable, non-steroidal SARM that can increase muscle mass and enhance the actions of testosterone without the side effects of synthetic steroids. Early studies and user reviews suggest it has better outcomes with minimal side effects, making it one of the most exciting and potent SARMs to date.


History of RAD140:

RAD140 is currently under development by the pharmaceutical company Radius. It was first described in 2010, which means research is limited. However, initial studies, company reports, and anecdotal user reviews are promising for muscle building without the side effects of synthetic steroids. Discovered through an internal discovery program, Testolone is being developed to treat breast cancer and muscle wasting in postmenopausal women. According to the company's website, the FDA has accepted their investigational new drug application, and the first human clinical trials were expected to start in 2017.


How RAD140 Works:

Androgen receptors (AR) are targeted by compounds like testosterone for normal human sexual development, but they also impact bones, muscles, liver, and the central nervous system. The issue within the medical and bodybuilding communities is that activating AR signaling with testosterone to increase muscle and bone development also affects sexual tissues, potentially leading to testicular atrophy, clitoral enlargement, and even the risk of prostate cancer.


RAD140, a non-steroidal selective androgen receptor modulator, circumvents this issue. Due to the way RAD140 binds to androgen receptors, different cells respond by releasing different proteins, and only some androgen receptors throughout the body are activated. This stimulation allows for the activation of androgen receptors in bone and muscle cells without increasing liver enzymes or affecting sexual tissues.


According to Radius, a pharmaceutical company based in Cambridge:

"…The potent, orally bioavailable and non-steroidal RAD140 is designed to make the hormone receptors in the tissues of the body act as though they are receiving a good dose of testosterone, triggering the same effects as if cycling with prohormones and anabolic steroids minus unwanted side effects…"


Benefits of RAD140:

Initial studies and user reports observe several major benefits:

  • RAD140 helps increase muscle mass.


  • The primary benefit of supplementing with RAD140 is its ability to increase lean tissue without increasing fat. In preliminary studies on monkeys, scientists observed an average weight increase of more than 10% in just 28 days using RAD140 alone, without any of the side effects traditionally associated with testosterone.






  • RAD140 can enhance speed, endurance, and stamina during high-intensity workouts.


  2. Want to train longer, harder, and achieve better results each time you hit the gym? It’s common to hear reports of improved speed, endurance, and stamina while supplementing with Testolone. Additionally, due to its ability to increase muscle tissue and decrease fat, each session of high-intensity training and interval training is optimized.








  • RAD140 has a greater anabolic effect than testosterone.


  2. Similar to other SARMs such as LGD4033 (Ligandrol) or S4 (Andarine), RAD140 produces similar results to testosterone but without the side effects. RAD140 interacts with hormonal receptors in muscles and bones in the same way as large doses of testosterone, all without the estrogenic side effects caused by anabolic steroids. Many forum users also report greater anabolic effects with RAD140 and sometimes use it as a PCT for steroid users to retain muscle mass between cycles.




  • RAD140 may reduce the side effects of testosterone.


  2. When used with synthetic steroids, preliminary studies suggest that RAD140 reduces the side effects of testosterone stimulation on the prostate and seminal vesicles of monkeys.


  4. Moreover, many steroid users report concerns about liver health. However, during a 28-day trial, these monkeys showed significantly lower liver enzyme elevations than doses ten times higher than the fully effective dose, even though they gained weight in a short period (which could potentially strain the liver).


  6. Our advice?


  8. Since the results of RAD140 have proven better than those using synthetic steroids, users might be better off forgetting testosterone and sticking with SARMs.


  10. Testosterone appears to lack the side effects on reproductive organs caused by synthetic steroids.


  12. Preliminary studies on mice found that a low dose of RAD140 is necessary to stimulate muscle growth without affecting prostate weight.


  14. This means RAD140 can selectively stimulate muscle and bone growth while reducing the impact on sexual tissues (such as the prostate or clitoris). Yes, this means RAD140 is safe for women.



  • RAD140 can aid in weight loss by increasing fat loss.


  2. RAD140 indirectly reduces body fat by increasing muscle and bone cells, which are metabolically more expensive to maintain than fat cells. By increasing muscle mass, an increase in metabolism is seen, which makes it easier to lose weight.


  4. Because RAD140 can increase endurance, stamina, and speed during interval training, users also report increased muscle growth and reduced fat storage.



  • RAD140 is being trialed for the treatment of breast cancer.


  2. RAD140 was discovered and is currently being developed by pharmaceutical company Radius specifically for the treatment of androgen receptor (AR) and estrogen receptor-positive (ER+) breast cancer in postmenopausal women.


  4. Completed in vitro studies in 2017 suggested that RAD140 inhibits the growth of AR/ER+ breast cancer cells. These studies support further research into RAD140 as a potential treatment for breast cancer and propose the first human clinical trials [refer to citation needed].



  • RAD140 is considered to have neuroprotective effects on brain health against neurodegenerative diseases.


  2. As male testosterone levels decline, the risk of disease in androgen-responsive tissues (including the brain) increases, which means the development of neurodegenerative diseases such as Alzheimer's.


  4. However, treating AR diseases with testosterone might increase the risk of developing prostate cancer. Recent studies suggest that RAD140 may be just as effective at reducing cell death as testosterone, without the side effects on the prostate [citation needed].


  6. RAD140 Side Effects


  8. Like most SARMs, studies suggest that RAD140 appears to be free of the common side effects of steroidal compounds. Unlike testosterone, RAD140 does not cause an enlarged prostate or testicular shrinkage.


  10. However, as it is still in the early stages of development, this does not mean there are no long-term effects. Some users report side effects such as headaches or insomnia, which disappear with the correct dosage.


  12. RAD140 Dosage Guidelines


  14. Testolone research is still ongoing, but it is known to have the same potency and efficacy as LGD4033.


  16. Studies on male primates suggest that 20-30mg every 24-36 hours is optimal for maximum skeletal hypertrophy, consistent with user anecdotal testimony. Studies have been safely conducted for up to 12 weeks, but developmental trials may indicate a tolerance for up to 24 weeks.


  18. It's worth noting that RAD140 systematically regulates the excitatory amino acid homocysteine, which activates glutamate receptors in the brain. Homocysteine's role in neuronal cell death (particularly in the hippocampus) has been shown to be a major cause of Alzheimer's disease. Medical research published by the Endocrine Society suggests that RAD140 can improve brain health in just 13 days through its neuroprotective properties (Jayaraman, 2014).


  20. Although safe for women, lower doses are advised. Women are recommended to take no more than 5mg per day, with a daily maximum of 10mg.


  22. Although there is no official human dosage for RAD140, its potency and efficacy have been compared to LGD4033.


  24. Current studies suggest that it can tolerate use for up to 12 weeks. We recommend that you do not exceed this 12-week period to achieve the best results.


  26. Rad140 vs. Ostarine


  28. To date, Ostarine is the most popular and successful SARM on the market. It is used for a wide range of fitness goals. Many athletes incorporate Ostarine into their diets to improve their athletic performance and enhance their muscle appearance.


  30. This compound is renowned for its amazing cutting abilities. It can shred your body fat super fast while maintaining muscle mass. Its results are very similar to synthetic anabolic steroids, but without the accompanying side effects. This means you don't have to worry about damaging your liver or heart health. Additionally, it does not cause high blood pressure, gynecomastia (man boobs), hair loss, acne, mood swings, and libido issues.

  31. In terms of fitness goals, RAD140 works in a very similar way to Ostarine. It not only helps build lean muscle mass but can also significantly increase strength levels. Additionally, it's a great tool for cutting purposes and building stamina. It can also be used to improve athletic performance.

  32. However, this compound is slightly more potent, so it's advised that beginners first opt for Ostarine before attempting to use RAD140.

  33. If your fitness goals include bulking, then RAD140 is definitely a better choice because it is more potent in this regard than Ostarine. You can expect significant muscle mass gains within an 8 to 12-week cycle. However, results will vary between individuals, but everyone can expect a substantial increase in lean muscle mass with RAD140.

  34. This compound lacks androgenic activity, which is a good thing because you don't have to worry about developing gynecomastia, hair loss, acne, liver toxicity, and high blood pressure. The cutting results of RAD140 and Ostarine are very similar. However, RAD140 does a better job of maintaining stubborn muscle and strength levels during cutting phases. This is mainly due to the compound's high anabolic ratio.

  35. Stacking

  36. While RAD140 is great on its own, it can be stacked with other SARMs to meet your personalized needs.

  37. Many users report stacking RAD140 (Testolone) with MK677 (Nutrobal) and MK2866 (Ostarine) to provide a powerhouse for building muscle, burning fat, promoting growth hormone, aiding joint recovery, and improving sleep.

  38. Testosterone is especially beneficial for older users who can reduce muscle loss, joint health, and restore sleep.

  39. Dosage:

  40. RAD140 (Testolone) - 30mg

  41. MK2866 (Ostarine) - 25mg

  42. MK677 (Nutrabol) - 20mg

  43. RAD140 is an ideal SARM for women and also helps increase women's muscle mass and reduce fat. We've found it to be the best compound for female athletes and bodybuilders It is the ideal combination

  44. RAD140 (Testolone) LGD4033 (Ligandrol) MK2866 (Ostarine) to achieve the best results. Final Review

  45. From compelling research provided by the latest scientific studies to the special muscle gains of anecdotal user reviews with very few side effects, it's hard not to see RAD140 as an essential supplement to your bodybuilding toolkit.

  46. Reportedly, RAD140 can provide results in as little as 4 weeks compared to other SARMs, but a cycle of up to 12 weeks is recommended for optimal results. Some user recommendations show amazing effects just after a 6-week cycle.

  47. Because it selectively targets muscle and bone tissue, RAD140 does not have the side effects caused by using steroids. This lack of side effects and minimal testosterone release makes RAD140 ideal for men and women seeking defined lean muscle and increased fat reduction. The only notable issue with RAD140 is the limited clinical human studies conducted in the scientific community. However, studies on non-human primates look promising and are consistent with anecdotal testimonials from the bodybuilding community.

  48. If you're looking for increased endurance, stamina, weight loss, and muscle gain without the side effects of testosterone, RAD140 is an excellent choice for your next cycle.

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