Description:

Trenbolone Acetate is an injectable synthetic anabolic steroid derived from nandrolone. However, its activity is completely distinct from its structural parent, making direct comparisons challenging. Trenbolone Acetate is a non-estrogenic steroid that is more potent per milligram in both anabolic and androgenic properties compared to nandrolone. In appearance, it is similar to androgens like Nortestosterone but more commonly used than nandrolone. It is estimated to be about three times as androgenically potent as testosterone, making it one of the strongest injectable anabolic steroids manufactured commercially. Among athletes, this steroid is highly valued for its ability to increase muscle hardness and raw strength, without unwanted water retention and fat gain. It is considered a top drug for competitive bodybuilders and remains popular among those simply looking to enhance their physical conditioning.

History:

Trenbolone Acetate was first studied in detail in 1967, following a series of anabolic steroid syntheses by Roussel-UCLAF. In the early 1950s, Hoechst sold trenbolone acetate in the UK as Finajet, and in France as Finaject. Hoechst AG of Germany was the parent company for both. Trenbolone acetate was marketed as a veterinary product but was also sold to humans as a long-acting ester (see: Parabolan). It was almost exclusively used to increase the weight of cattle about to be slaughtered and improve feed efficiency. Essentially, the drug was used to increase profit per kilogram of weight. It was used continuously until slaughter, with no withdrawal period. As a result, meat sold in many parts of the world often contained trace amounts of trenbolone metabolites.

In the 1980s, trenbolone acetate first became popular among bodybuilders in the United States, where the drug was smuggled in large quantities from Europe. It was recognized (rightly) as a potent anabolic and androgenic agent and quickly became a preferred drug among American bodybuilders. Despite its popularity, in 1987, Hoechst-Roussel voluntarily discontinued all injectable forms of the drug, possibly in response to increasing public scrutiny of performance-enhancing drugs, as discontinuing “controversial” steroids was common in the late 1980s and early 1990s. This marked the end of the legal production of trenbolone acetate.

As we saw the disappearance of Finajet and Finaject, Hoechst-Roussel introduced Finaplix cattle implants to the U.S. market, which were approved by the FDA in 1987. These pellets were designed to be implanted in cattle ears using a handheld implant gun, and were too large to be implanted in humans. Notably, trenbolone acetate pellets were exempt from the U.S. Controlled Substances Act, possibly to make it easier and more affordable for livestock owners to use growth promoters. If a veterinarian were to require this medication frequently, the cost would be prohibitively high. Indeed, because these products were presented in pellet form, they were not suitable for human consumption.

The ability to manufacture usable Finaplix pellets for humans might be difficult, but it is still widely applied. The most common method is to grind two to four implant pellets and mix them with a 50/50 solution of water and DMSO, applying it to the skin daily. This homemade transdermal mixture is effective but carries a strong garlic odor (due to DMSO). Others have ground a few pellets with the back of a spoon and inhaled (snorted) them. In this case, the drug enters the bloodstream via the mucous membranes, a crude but still useful means of steroid hormone delivery. Those who have tried this method often claim it's not as harsh as one might imagine. Some athletes even choose to simply ingest the drug. Although not the ideal delivery method, the oral bioavailability can reach moderate levels, allowing the drug to be used in this manner with appropriate dosages.

Some more adventurous individuals have mixed their own injections with Finaplix. They grind the pellets into a fine powder (usually 2 to 6 pellets worth), then mix it into sterile water, propylene glycol, or oil-based injectable steroids or veterinary vitamins. Typically repeated twice a week, though some do it more frequently. As this is done in an uncontrolled non-sterile environment, there is obviously a risk of infection (or worse). Starting in the late 1990s, some shops began selling kits containing all the necessary components to separate the active steroid from the binder and create a relatively pure injectable solution. These kits have been popular over the years and often have repeat customers, although it is not considered a replacement for sterile medications.

Finaplix is currently available in the U.S. and some foreign markets, though now sold by Intervet instead of Hoechst-Roussel Agri-vet. The product is available in two forms, Finaplix-H and Finaplix-S, indicating whether the product is intended for heifers or steers. The total dosage of the two products differs; the "H" type contains 100 20mg trenbolone acetate pellets (2,000mg total), while the "S" type contains only 70 pellets (1,400mg total). Ivy Animal Health (USA) has launched two competing products, sold as Component-TH and Component-TS. There are also the Revalor and Synovex+ brands, which contain additional doses of estrogen (usually unnecessary) with trenbolone acetate. Additionally, while there are no other legal pharmaceutical manufacturers of trenbolone acetate, many export and underground steroid manufacturers produce (for injection and oral use) this medication.

Specifications Provided:

Trenbolone acetate is available in specific veterinary markets. It is usually sold in the form of implant pellets, each containing 20mg of trenbolone acetate. Formerly, injectable preparations containing 30mg/ml of steroid in oil were sold.

Structural Characteristics:

Trenbolone acetate is a modified form of nandrolone. Its distinction lies in the introduction of double bonds at carbons 9 and 11, which inhibits aromatization (9-ene) and increases androgen receptor binding affinity, and slows its metabolism. The resulting steroid has stronger anabolic and androgenic effects compared to nandrolone. Trenbolone acetate contains a chemotactic factor modified by the addition of a carboxylic acid ester (acetate) at the 17-β hydroxyl group, allowing the free steroid to be released slowly in the injection area.

Side Effects (Estrogenic):

Trenbolone acetate is not aromatized by the body, and no estrogenic activity has been detected. However, it is noteworthy that this steroid exhibits significant binding affinity to progesterone receptors (slightly stronger than progesterone itself). Progestogenic side effects are similar to those of estrogen, including negative feedback suppression of testosterone production and enhanced fat storage rates. Progesterone also increases the stimulatory effect of estrogen on mammary tissue growth. There seems to be a strong synergistic interaction between these two hormones, so gynecomastia could potentially occur under the influence of progesterone even without excessive estrogen levels. The use of anti-estrogens that inhibit the components of estrogen is usually sufficient to mitigate gynecomastia caused by progestational synthetic anabolic/androgenic steroids. Note that inflammatory side effects are more common when using other aromatizable steroids.

Side Effects (Androgenic):

Although classified as an anabolic steroid, trenbolone acetate still has sufficient androgenicity. Androgenic side effects are frequently observed when using this drug, which may include oily skin, acne, and episodes of body/facial hair growth. Anabolic/androgenic steroids can also exacerbate male pattern baldness. Female users are cautioned about the potential virilizing effects of anabolic/androgenic steroids. These might include deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Additionally, 5-α reductase does not metabolize trenbolone acetate, therefore its relative androgenicity is not influenced by finasteride or dutasteride.

Side Effects (Hepatotoxicity):

Trenbolone acetate is not c-17α alkylated and is generally not considered a hepatotoxic steroid; thus, liver toxicity is unlikely to occur. However, this steroid has strong resistance to hepatic breakdown, and severe liver toxicity has been noted in bodybuilders abusing trenbolone acetate treatment. Although unlikely, hepatotoxicity cannot be completely ruled out, especially at high doses.

Side Effects (Cardiovascular):

Anabolic/androgenic steroids can have detrimental effects on serum cholesterol. This includes a tendency to lower HDL (good) cholesterol values and increase LDL (bad) cholesterol values, potentially shifting the HDL to LDL balance and thereby increasing the risk of arteriosclerosis. The relative impact of anabolic/androgenic steroids on serum lipids depends on the dose, route of administration (oral vs. injection), the type of steroid (aromatizable or non-aromatizable), and the level of resistance to hepatic metabolism. Due to its non-aromatizable nature and strong resistance to metabolism, trenbolone acetate has a moderate to strong (negative) impact on lipid values and arteriosclerosis risk. Anabolic/androgenic steroids can also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and lead to left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.

To help reduce cardiovascular strain, it is advised to maintain an active cardiovascular exercise program and to minimize the intake of saturated fats, cholesterol, and simple carbohydrates during AAS use. It is also recommended to supplement with fish oil (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a similar product.

Side Effects (Testosterone Suppression):

When taken at doses sufficient to promote muscle gain, all anabolic/androgenic steroids are expected to suppress endogenous testosterone production. Without intervention from testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months after the drug ceases. Please note that prolonged hypogonadal states can develop secondary to steroid abuse and require medical intervention. In experimental studies, trenbolone acetate's suppression of gonadotropins per milligram is about three times that of testosterone.

For a more detailed discussion of other potential side effects, please refer to the section on steroid side effects in this book.

Use (Male):

Trenbolone acetate has never been approved for human use. No prescription guidelines are available. For physique or performance enhancement purposes, effective doses typically range from 100-300 mg per week, taken for 6 to 8 weeks. Due to the short action of the acetate ester, the total weekly dose can be split into 2-3 smaller doses. Effective oral doses are often in the range of 100-200mg per day, not to exceed 6-8 weeks, to minimize any potential liver strain. This level is sufficient to notice strong increases in strength and lean tissue mass, with low levels of side effects. The lack of estrogenic activity makes trenbolone acetate very attractive to athletes who are cutting, while also trying to avoid water retention. Here, trenbolone acetate can provide high androgenicity for achieving a very hard and strong physique.

Although it is a notable hardener, this is not the only benefit of trenbolone acetate. It is also a potent anabolic, and muscle gains can be comparable to those with testosterone and Dianabol, yet without the same level of water retention. This might be an exaggerated description, as the lack of estrogenic activity seems to diminish the agent’s ability to promote muscle mass gains. Although often recommended as a great supplement to a mass cycle, it is rarely reported as a very potent agent when used alone. The most commonly reported results are moderate lean tissue growth accompanied by special hardening and fat loss. If pure mass is the goal, then it is not as effective as estrogenic bulking agents, but trenbolone acetate per milligram is still better than nandrolone and possibly the most anabolic of all non-estrogenic commercial steroids.

For stacking, trenbolone is a very versatile steroid and seems to work exceptionally well with other agents for both bulking and cutting purposes. For cutting, bodybuilders often use mild anabolics like Winstrol or Primobolan. There is no extra water under your skin, and the mixture will provide a very solid, definite hardness to your physique. For lean mass gains, Deca-Durabolin or Equipoise are popular choices. Here again, trenbolone acetate can greatly enhance and solidify new muscle growth. When seeking pure mass, trenbolone is a better choice for testosterone, Anadrol50, or Dianabol. The results are usually some solid muscle mass fast and substantive gains. In “The Underground Steroid Handbook II,” Dan Duchaine noted that a mixture of trenbolone, testosterone, and Anadrol was the most effective combination for men, stating, “I have not found any other stack that is as potent for mass and strength gains.” This particular drug combination has become very popular.

Use (Female):

Trenbolone acetate has never been approved for human use. No prescription guidelines are available. Due to its strong androgenic nature and tendency to produce virulent side effects, this drug is not recommended for women for physique or performance enhancement purposes.

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