Description:

Testosterone propionate is an injectable steroid derived from dihydrotestosterone, where the dihydrotestosterone structure is modified with a 2-methyl group, enhancing its anabolic capabilities, making it more effective in promoting muscle growth compared to testosterone. Some literature describes testosterone propionate as a "powerful anabolic steroid and anti-estrogen medication," possessing both anabolic and anti-estrogenic properties. However, its anabolic nature is considered moderate, especially when used with other agents. This drug is most commonly used by bodybuilders on a diet or athletes in speed training, as it can increase muscle hardness, the amount of lean muscle, and muscle strength while reducing body fat levels and minimizing side effects.

History:

Drostanolone was first introduced in 1959, alongside other well-known steroids such as "Winstrol" by Syntex. However, it was not used as a prescription drug until about ten years after its introduction. Eli Lilly and Syntex reached an agreement to share certain development costs in exchange for rights to market research findings. Thus, in the U.S. market, it was sold under the name of testosterone propionate by Eli Lilly, while other markets were owned by Syntex. Here are the licensing and sales situations of a range of products including drostanolone in other countries: Sarva-Syntex in Belgium, Cilag in Portugal, Masteril in the UK and Bulgaria, and Metormon in Spain. Drostanolone propionate also became popular in other places under the names Permastril (Cassenne in France), Mastisol (Yamanouchi in Japan), and Masterid (Grünenthal in Germany).

The FDA approved testosterone propionate for the treatment of advanced post-menopausal breast cancer, which also represents the FDA’s clinical guidance on drostanolone in the international market. Research literature also reminds doctors and female patients that masculinization reactions in patients taking testosterone propionate are less than those taking testosterone propionate. Thus, drostanolone is a more reassuring testosterone injection alternative. However, an injection dose of 300 mg/week is considered relatively high. The product information also warns that common mild masculinization symptoms such as voice deepening, worsening acne, facial hair growth, and clitoral enlargement can occur. Studies also report that if treated long-term, masculinization features will be more prominent.

In the 1970s and 1980s, drostanolone enjoyed a high reputation among athletes. However, the good times did not last long as manufacturers began to stop selling this drug. This might be due to more effective treatments for breast cancer becoming available, as well as a slow reduction in steroid prescriptions during this period. The first to prepare for market withdrawal was testosterone propionate in the U.S., which exited the market around the 1980s. Subsequently, market shares in France and Spain also decreased. In Western countries, drostanolone last disappeared in the late 1990s. However, drostanolone is still sold in the U.S. Pharmacopias without legal restrictions, although it is unlikely to reappear as a prescription drug product.

Specifications Provided:

Drostanolone is not available as a prescription drug. When manufactured, it comes in 1mL and 2mL vials, stored in oil-based solutions of 50mg/ml and 100mg/ml.

Structural Characteristics:

Drostanolone is a modified form of dihydrotestosterone. It exhibits different properties by introducing a methyl group at carbon-2 (α), significantly increasing the steroid’s anabolic strength by enhancing its resistance to metabolic breakdown by 3-hydroxysteroid dehydrogenase in skeletal muscle tissue. Propionate drostanolone is a modified form of drostanolol, where the carboxylic acid ester (propionate) has been attached to the 17-β hydroxyl group. Esterified steroids are less polar than free steroids and are absorbed slower from the area of injection. Once in the bloodstream, the ester is removed to yield free (active) drostanolol. Esterified steroids are designed to extend the therapeutic effect window after administration, allowing less frequent injections compared to administering free (unesterified) steroids. The half-life of testosterone propionate is approximately two days after injection.

Side Effects (Estrogenic):

Drostanolone cannot be aromatized by the body, and no estrogenic activity has been detected. Using this steroid does not require anti-androgens because even individuals with sensitive constitutions will not experience gynecomastia. Since estrogen can maintain water retention, drostanolone can make you appear leaner without worrying about excessive subcutaneous water retention. So when there is water and fat deposition in the body, drostanolone is a good hormonal choice. As a non-aromatizable DHT derivative, drostanolone can produce anti-estrogenic effects, competing with other aromatizable substances to bind to aromatase.

Side Effects (Androgenic):

Although classified as an anabolic steroid, drostanolone can still produce androgenic side effects, especially when used above normal therapeutic doses. These might include a range of effects: oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids can also exacerbate male pattern baldness. Female users should be aware that possible reactions include: menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Drostanolone is a steroid with relatively low androgenic activity compared to its tissue-building actions, thus making the threshold for androgenic side effects quite high compared to androgenic drugs such as testosterone, methyltestosterone, or fluoxymesterone. Note that drostanolone is not affected by 5-α reductase, so it is not influenced by the simultaneous use of finasteride or dutasteride.

Side Effects (Hepatotoxicity):

Drostanolone has not undergone C17α-alkylation and has not been shown to have hepatotoxicity, so the occurrence of liver toxicity is unlikely.

Side Effects (Cardiovascular):

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to lower HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance, thereby increasing the risk of arteriosclerosis. The relative impact of anabolic/androgenic steroids on serum lipids depends on the dose, the route of administration (oral vs. injection), the type of steroid (aromatizable or non-aromatizable), and the level of resistance to hepatic metabolism. Due to its non-aromatizable nature, drostanolone has a stronger negative impact on cholesterol treatment in the liver than testosterone or nandrolone but is weaker than the impact of C-17α-alkylated steroids. Anabolic/androgenic steroids can also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and lead to left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.

To help reduce cardiovascular strain, it is advised to maintain an active cardiovascular exercise program and to minimize the intake of saturated fats, cholesterol, and simple carbohydrates during AAS use. It is also recommended to supplement with fish oil (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a similar product.

Side Effects (Testosterone Suppression):

When taken at doses sufficient to promote muscle gain, all anabolic/androgenic steroids are expected to suppress endogenous testosterone production. Without intervention from testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months after the drug ceases. Please note that prolonged hypogonadal states can develop secondary to steroid abuse and require medical intervention.

For a more detailed discussion of other potential side effects, please refer to the section on steroid side effects in this book.

Therapeutic (Male):

Testosterone propionate is not FDA-approved for use in males. No prescription guidelines are available. For physique or performance enhancement purposes, the drug is typically injected three times per week. The total weekly dosage usually ranges from 200-400mg, taken for 6-12 weeks. This level of use is sufficient to provide measurable gains in lean muscle mass and strength.

Testosterone propionate is often combined with other steroids to enhance effects. Common stacks include injectable anabolics such as Deca-Durabolin (nandrolone decanoate) or Equipoise (boldenone undecylenate), which can provide substantial muscle enhancement without excessive water retention. For mass gain, it is often combined with injectable testosterone. These combinations can achieve solid muscle gains with lower levels of water retention and estrogenic side effects compared to using these steroids alone (typically at higher doses). However, testosterone propionate is most commonly used during the cutting phases of training. In this case, it is usually combined with other non-aromatizable steroids such as Winstrol, Primobolan, Parabolan, or Anavar, which can significantly aid in muscle retention and fat reduction.

Therapeutic (Female):

The prescription guidelines for testosterone propionate suggest administering three times per week, with a total dose of 100mg. Treatment should be given for at least 8 to 12 weeks before assessing efficacy. If successful, the medication can continue as long as satisfactory results are obtained. Please note that virilization symptoms are common at the recommended dose. When used for physical or performance enhancement purposes, a common dose is 50mg per week, lasting 4 to 6 weeks. Doses of 100mg per week or less rarely exhibit virilization symptoms. Note that due to the short action of the propionate ester, the total weekly dose is usually divided into smaller injections given every other to every third day.

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