Description:

Nandrolone Decanoate is an injectable form of the anabolic steroid nandrolone. The decanoate ester provides a slow release of nandrolone from the injection site, lasting for up to three weeks. Structurally similar to testosterone, nandrolone lacks a carbon atom at the 19th position (hence its other name, 19-nortestosterone). Like testosterone, nandrolone has relatively strong anabolic properties. However, unlike testosterone, its tissue-building activity comes with reduced androgenic effects. Most of nandrolone is weakened into a less potent steroid through conversion to DHT. The mild nature of Nandrolone Decanoate makes it one of the most popular injectable steroids globally, highly favored by athletes for its significant increase in strength and lean muscle mass without strong androgenic or estrogenic side effects.

History:

Nandrolone Decanoate first appeared in 1960 and was available as a prescription drug by 1962, developed by the international pharmaceutical giant Organon under the brand name Deca-Durabolin. Containing a 10-carbon atom ester, decanoate, it is a variant of the previously popular injectable nandrolone (Nandrolone Phenylpropionate). Its release significantly broadened the market for nandrolone decanoate. Perhaps due to its effective performance and broad market presence, it quickly became one of the most widely distributed anabolic steroids globally.

When first introduced in the United States, nandrolone decanoate (as Deca-Durabolin) was prescribed for various medical conditions. Indications included pre- and postoperative weight gain, osteoporosis, advanced breast cancer, weight loss due to convalescence or disease, geriatric conditions (general weakness and debility), burns, severe trauma, ulcers, anemia, and delayed puberty in children. Initially sold in 50mg/ml dosage due to the very low doses recommended (typically 50-100mg every 3-4 weeks), it soon updated to a 100mg/ml version because some cases required higher doses, especially for intractable anemia and advanced breast cancer. Later on, Organon also released a 200mg/ml product.

Despite the drug's widespread medical use for about a decade, by the mid-1970s, the applications of nandrolone decanoate in the U.S. and overseas were refined. The FDA in 1975 revised its prescription information, listing nandrolone decanoate as "possibly effective" as an adjunct therapy for geriatric and postmenopausal osteoporosis, and for treating pituitary-deficient dwarfism until more growth hormone became available. It was also considered helpful in maintaining lean mass, controlling advanced breast cancer, and assisting in certain types of anemia. More often, it was used to explore other potential "less effective" uses.

The modern (approved) medical uses of the drug are more refined than in the mid-1970s. In the United States, it is now only used to treat anemia, although it is often "off-label" used to maintain lean mass in HIV-positive patients and others with wasting diseases. Outside the U.S., Organon appears to primarily treat patients with severe anemia, osteoporosis, and advanced breast cancer. Organon's Nandrolone Decanoate is still widely available today, now distributed by the new parent company, Merck/MSD. Additionally, in many countries, Nandrolone Decanoate is also a generic drug, produced by numerous other unique brands.

Specifications Provided:

Nandrolone Decanoate is widely sold in both human and veterinary markets. Composition and dosage may vary by country and manufacturer, but it typically contains 25mg/ml, 50mg/ml, 100mg/ml, or 200mg/ml of steroid dissolved in oil.

Structural Characteristics:

Nandrolone Decanoate is a modified form of nandrolone, where the carboxylic acid ester (decanoate) is attached to the 17-β hydroxyl group. Esterified steroids are less polar than free steroids and are absorbed more slowly from the injection area. Once in the bloodstream, the ester is removed to produce free (active) nandrolone. Esterified steroids are intended to prolong the therapeutic effect window after administration, allowing for less frequent injections compared to administering free (unesterified) steroids. After a deep intramuscular injection, nandrolone decanoate provides a peak release of nandrolone within 24-48 hours, steadily declining to near baseline levels approximately two weeks later. The half-life of Nandrolone Decanoate is about 7-12 days.

Side Effects (Estrogenic):

Nandrolone has a lower tendency for estrogen conversion, estimated to be approximately 20% of that of testosterone. This is because the liver can convert nandrolone to estradiol in other more active sites of steroid aromatization such as adipose tissue. Nandrolone's estrogen-related side effects are much less pronounced compared to testosterone. However, elevated estrogen levels from high doses can still occur and may cause side effects such as increased water retention, body fat gain, and gynecomastia. Anti-estrogens such as clomiphene citrate or tamoxifen citrate may be necessary to prevent estrogenic side effects. Aromatase inhibitors such as anastrozole can be used to more effectively control estrogen by preventing its synthesis. However, compared to anti-estrogens, aromatase inhibitors can be quite expensive and may also have a negative impact on blood lipids.

Side Effects (Androgenic):

Although classified as an anabolic steroid, the substance can still produce androgenic side effects, especially at higher doses. These side effects may include oily skin, acne, and body/facial hair growth episodes. Anabolic/androgenic steroids can also accelerate male pattern baldness. Female users are cautioned about the potential virilizing effects of anabolic/androgenic steroids. These side effects may include deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Nandrolone is a steroid with relatively low androgenic activity compared to its tissue-building effects, making the threshold for androgenic side effects quite high compared to androgenic drugs such as testosterone, methyltestosterone, or fluoxymesterone. It is also important to note that due to its mild androgenic nature and suppression of endogenous testosterone, nandrolone can interfere with male libido when not using another androgen.

Note: In androgen-responsive target tissues such as the skin, scalp, and prostate, nandrolone's relative androgenicity is reduced by being converted to dihydronandrolone (DHN). 5-α reductase is responsible for this metabolism. Simultaneous use of 5-α reductase inhibitors such as finasteride or dutasteride can reduce the site specificity of nandrolone's action, thereby significantly increasing the tendency for nandrolone to produce androgenic side effects. If low androgenicity is desired, reductase inhibitors should be avoided in combination with nandrolone.

Side Effects (Hepatotoxicity):

Nandrolone is not c-17α alkylated and has not shown hepatotoxic effects in healthy subjects, so liver toxicity is unlikely.

Side Effects (Cardiovascular):

Anabolic/androgenic steroids can have detrimental effects on serum cholesterol. This includes a tendency to lower HDL (good) cholesterol values and increase LDL (bad) cholesterol values, potentially shifting the HDL to LDL balance and thereby increasing the risk of arteriosclerosis. The relative impact of anabolic/androgenic steroids on serum lipids depends on the dose, route of administration (oral vs. injection), the type of steroid (aromatizable or non-aromatizable), and the level of resistance to hepatic metabolism. A study administering 600mg of Nandrolone Decanoate per week for 10 weeks showed a 26% reduction in HDL cholesterol levels. This suppression is slightly higher than that reported with the same dosage of Testosterone Cypionate and is more potent compared to earlier studies with Testosterone Propionate. Compared to c-17α alkylated agents, Nandrolone Decanoate has a significantly weaker effect on serum lipids. Anabolic/androgenic steroids can also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and lead to left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.

To help reduce cardiovascular strain, it is advised to maintain an active cardiovascular exercise program and to minimize the intake of saturated fats, cholesterol, and simple carbohydrates during AAS use. It is also recommended to supplement with fish oil (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a similar product.

Side Effects (Testosterone Suppression):

When taken at doses sufficient to promote muscle gain, all anabolic/androgenic steroids are expected to suppress endogenous testosterone production. A study administering 100mg of Nandrolone Decanoate per week for 6 weeks showed a reduction in serum testosterone levels by about 57%. At a dosage of 300mg per week, this reduction reached 70%. Although the tendency to convert to estrogen is minimal, nandrolone's progestogenic activity significantly aids in suppressing testosterone synthesis during treatment. Without intervention from testosterone-stimulating substances, testosterone levels should return to normal within 2-6 months after the drug is discontinued. Please note that prolonged hypogonadotropic hypogonadism can develop secondary to steroid abuse and require medical intervention.

For a more detailed discussion of other potential side effects, please refer to the section on steroid side effects in this book.

Therapeutic Guidance (Male):

For general anabolic effects, early prescription guidelines recommended a dose of 50-100mg every 3-4 weeks for 12 weeks. For the treatment of renal anemia, the prescription guidelines for Nandrolone Decanoate recommend a dose of 100-200mg per week. Commonly used doses for physical or performance enhancement purposes range from 200-600mg per week, for a duration of 8 to 12 weeks. This level is sufficient for most users to provide measurable gains in lean muscle mass and strength. Using Nandrolone Decanoate at 2mg per pound of body weight per week shows the best effects (optimal gain/side effect ratio), although individual differences may determine the ideal dosage for different users. Nandrolone Decanoate is not a very "fast" builder; the drug produces significant but not dramatic muscle effects. Generally, the rate at which individuals build muscle mass with Nandrolone Decanoate is about half that achieved with an equivalent dose of testosterone.

Nandrolone Decanoate is often combined with other steroids to enhance effects. For example, combining 200-400mg/week of Nandrolone Decanoate with 10-20mg per day can significantly enhance the appearance of muscles and the effects during dieting/cutting phases. Strong non-aromatizing androgens such as Fluoxymesterone or Trenbolone can again provide a higher level of hardness and density to the muscles. As a moderately strong muscle builder, nandrolone can also be added to bulking cycles, yielding acceptable results. The classic "Deca and D-bol" stack (usually 200-400mg of Nandrolone Decanoate per week with 15-25mg of Dianabol per day) has been a staple in bodybuilding for decades, always providing excellent muscle growth. Stronger androgens such as Trenbolone or testosterone can be used to replace, producing larger results but with greater water retention.

Therapeutic Guidance (Female):

For general anabolic effects, early prescription guidelines recommend a dose of 50-100mg every 3-4 weeks for 12 weeks. For the treatment of renal anemia, the prescription guidelines for Nandrolone Decanoate recommend a dose of 50-100mg per week. When used for physical or performance enhancement purposes, a common dose is 50mg per week, taken for 4-6 weeks. Although only mildly androgenic, when women take this compound, virilization symptoms occasionally occur. Studies have shown a tolerable regimen of 100mg every other week for 12 weeks, while long-term studies (over 12 months) show that doses as low as 50mg every 2-3 weeks can have virilizing effects. If side effects occur, Nandrolone Decanoate should be discontinued immediately to prevent permanent effects. After an adequate period of withdrawal, short-acting oral Metenolone is considered a safer option. This drug remains active for only a few days, significantly reducing the downtime if significant side effects appear.

Prev: Trenbolone Acetate

Next: Testosterone enanthate

热门CYCLE

肽类循环-1

职业级减脂11

职业级减脂10

中级减脂-15

初级减脂-11

初级减脂-10