Masteron

Description:

Drostanolone propionate is an injectable steroid derived from dihydrotestosterone, where the DHT structure has been modified with a 2-methyl group to enhance its anabolic capabilities, making drostanolone more effective than testosterone in promoting muscle growth. It is described in some literature as "a potent anabolic steroid and anti-estrogenic drug," indeed possessing both anabolic and anti-estrogenic properties. However, its anabolic nature is considered moderate, especially when used in conjunction with other agents. This drug is most commonly used by bodybuilders on a diet or athletes in speed training to enhance muscle hardness, increase lean muscle mass, and reduce body fat levels while minimizing side effects.

History:

Drostanolone was first introduced in 1959, along with another famous steroid, "Drolban." However, it was about ten years later that drostanolone was used as a prescription drug. Eli Lilly and Syntex Pharmaceuticals reached an agreement to share certain research and development costs in exchange for marketing rights. Thus, in the U.S. market, it is sold under the name of drostanolone propionate by Eli Lilly, while in other markets, it is owned by Syntex. The drug, including drostanolone, is licensed for sale in other countries by various companies: Sarva-Syntex in Belgium, Cilag in Portugal, Masteril in the UK and Bulgaria, Metormon in Spain. Drostanolone propionate is also popular in other regions under names like Permastril (Cassenne in France), Mastisol (Yamanouchi in Japan), and Masterid (Grünenthal in Germany).

The FDA approved drostanolone propionate for the treatment of postmenopausal women with advanced breast cancer, which is also the clinical guidance for drostanolone on the international market. Research literature also suggests that the masculinization response in patients taking drostanolone is less pronounced compared to those taking testosterone propionate, making drostanolone a more reassuring choice for androgen replacement therapy. However, an injection dose of 300mg/week is considered relatively high. The literature warns that mild virilization, such as voice deepening, worsening acne, facial hair growth, and clitoral enlargement, generally occurs. Studies also report that long-term treatment leads to more pronounced masculinization traits.

During the 1970s and 1980s, drostanolone enjoyed a high reputation among athletes. However, manufacturers began to cease the agency sales of this drug, possibly due to the emergence of more effective treatments for breast cancer and a slow reduction in the prescription of steroids during this period. The first to prepare for market departure was drostanolone propionate in the U.S., which exited the market around the 1980s. The market shares in France and Spain also decreased. In Western countries, drostanolone finally disappeared in the late 1990s. However, drostanolone is still available in the U.S. Pharmacopias and is not legally restricted in the market, although its reappearance as a prescription drug seems unlikely.

Available Forms:

Drostanolone is not available as a prescription drug. When manufactured, it comes in 1ML and 2ML vials, stored in oil at concentrations of 50mg/ml and 100mg/ml.

Structural Features:

Drostanolone is an altered form of dihydrotestosterone. It exhibits different performance characteristics by incorporating a methyl group at the carbon-2 (α) position, significantly increasing the steroid's anabolic strength by enhancing its resistance to metabolic breakdown by 3-hydroxysteroid dehydrogenase in skeletal muscle tissue. Drostanolone propionate is a modified form of drostanolone, where a carboxylic acid ester (propionate) has been attached to the 17-beta hydroxyl group. Esterified steroids are less polar and absorb slower from the injection site. Once in the bloodstream, the ester is removed to yield free (active) drostanolone. Esterified steroids are designed to prolong the therapeutic effect post-administration, allowing less frequent injections compared to free (unesterified) steroids. The half-life of drostanolone propionate is about two days post-injection.

Side Effects (Estrogenic):

Drostanolone cannot be aromatized by the body and exhibits no estrogenic activity. Using this steroid does not require anti-androgens since even individuals with a sensitive constitution will not experience gynecomastia. Since estrogen can retain water, drostanolone can maintain a leaner appearance without the concern of excessive subcutaneous water retention. Thus, when there is water and fat deposition in the body, drostanolone is a good hormonal choice. As a non-aromatizable DHT derivative, drostanolone can exhibit anti-estrogenic effects by competing with other substances for binding to aromatase.

Side Effects (Androgenic):

Although categorized as an anabolic steroid, drostanolone can still potentially produce androgenic side effects, especially when used above the normal therapeutic doses. This may include a range of side effects: oily skin, acne, body/facial hair growth. Anabolic/androgenic steroids might also exacerbate male pattern baldness. Female users should be aware of potential reactions such as menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Drostanolone is a steroid with relatively low androgenic activity compared to its tissue-building action, making its side effects threshold quite high compared to androgenic drugs like testosterone, methyltestosterone, or fluoxymesterone. Note that drostanolone is not affected by 5-alpha reductase, so its use is not influenced by finasteride or dutasteride.

Side Effects (Hepatotoxicity):

Drostanolone is not C17α-alkylated and has not been proven to exhibit hepatotoxicity, so the likelihood of liver toxicity is minimal.

Side Effects (Cardiovascular):

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance and lead to greater arteriosclerosis risk. The relative impact of anabolic/androgenic steroids on serum lipids depends on the dose, the administration method (oral vs. injection), the type of steroid (aromatizable or non-aromatizable), and the level of resistance to hepatic metabolism. Due to its non-aromatizable nature, Drostanolone has a more adverse effect on cholesterol management than testosterone or nandrolone but is less than that of C-17α-alkylated steroids. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and lead to left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.

To help reduce cardiovascular strain, it is advised to maintain an active cardiovascular exercise program and always minimize the intake of saturated fats, cholesterol, and simple carbohydrates during AAS use. It is also recommended to supplement with fish oil (4 grams per day) and natural cholesterol/antioxidant formulas like Lipid Stabil or a product with similar ingredients.

Side Effects (Testosterone Suppression):

All anabolic/androgenic steroids, when taken in doses sufficient to promote muscle gain, are expected to suppress endogenous testosterone production. Without stimulants of testosterone, levels should return to normal within 1-4 months post-drug cessation. Note that prolonged hypogonadotropic hypogonadism can develop secondary to steroid abuse and requires medical intervention.

For a more detailed discussion of other potential side effects, please refer to the Steroid Side Effects section of this book.

Therapy (Men):

Drostanolone propionate is not FDA-approved for use in men. Prescription guidelines are unavailable. For physique or performance enhancement purposes, the drug is typically administered three times per week. The total weekly dosage is usually 200-400mg, taken for 6-12 weeks. This level of use is sufficient to provide measurable gains in lean muscle mass and strength.

Drostanolone propionate is often combined with other steroids to enhance effects. Common stack includes injectable anabolics like Deca-Durabolin (nandrolone decanoate) or Equipoise (boldenone undecylenate), which can provide substantial muscle gain without excessive water retention. For mass gains, it is usually combined with injectable testosterone. These combinations can achieve solid muscle mass with lower levels of water retention and estrogenic side effects compared to using these steroids alone (usually at higher doses). However, drostanolone propionate is most commonly used during the cutting phases of training. In such cases, it is typically combined with other non-aromatizable steroids like Winstrol, Primobolan, Parabolan, or Anavar, which can significantly aid in muscle retention and fat reduction.

Therapy (Women):

The prescription guidelines for drostanolone propionate recommend administering it three times per week, with a total dosage of 100mg. Treatment should be given for at least 8 to 12 weeks before assessing efficacy. If successful, the drug can be continued as long as satisfactory results are obtained. Note that virilization symptoms are common at the recommended dosage. When used for physical or performance enhancement purposes, the most common dose is 50mg per week for 4 to 6 weeks. Masculinization symptoms are rare at doses of 100mg per week or less. Note that due to the short action of the propionate ester, the total weekly dosage is usually divided into smaller injections given every other day to every three days.

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