Product Description:

Injectable methenolone represents an injectable form of the steroid methenolone, structurally similar to its oral counterpart but featuring an enanthate ester that slowly releases from the injection site post-administration. Methenolone enanthate provides a testosterone-like release pattern, maintaining elevated blood hormone levels for approximately two weeks. Methenolone itself is a moderately strong steroid with very low androgenicity. Its anabolic rating is slightly less than that of nandrolone decanoate (Deca). It is most commonly used during phases aimed at shaping and defining muscles, focusing on lean muscle gain rather than bulk.

Product History:

Methenolone was introduced in 1960 and entered the U.S. prescription drug market in 1962 under Squibb’s trade name, Nibal. That same year, Squibb transferred the rights to Schering AG, who marketed it under the name Primobolan® Depot. During the 1960s and 1970s, injectable methenolone was primarily circulated in the European market, including countries like Switzerland, Italy, Germany, Austria, Belgium, France, Portugal, and Greece.

Schering held the patent rights to methenolone until the late 1970s. Prior to the expiration of its patent, Schering rigorously defended its rights, even in the U.S., where other companies were not allowed to produce or distribute methenolone. Although methenolone has been off the U.S. market for over a decade, it retains its status as an FDA-approved drug.

Methenolone is regarded as a good anabolic steroid for building lean muscle mass and is commonly used for conditions involving muscle wasting with concurrent infections, major surgery, catabolic diseases, corticosteroid overuse, and during recovery phases. Some doctors prescribe it for osteoporosis, muscle atrophy (natural muscle wasting), chronic hepatitis, and breast cancer (usually as an adjunct therapy). In pediatric clinical studies, this steroid has proven effective in increasing the body weight of premature infants without showing hepatotoxicity or adverse reactions. Athletes favor it for its strong anabolic properties, weak androgenicity, and lack of estrogenicity, making methenolone an ideal choice for increasing lean muscle mass.

Despite methenolone's safe clinical record, Schering, now a multinational pharmaceutical giant, withdrew the drug from most countries in the late 1990s amid renewed scrutiny over performance enhancers. Today, the brand is only sold in a few countries, including Spain, Turkey, Japan, Paraguay, and Ecuador. With limited availability, Bayer almost monopolizes the production of methenolone globally. However, in recent years, methenolone has also circulated through other channels such as underground manufacturers or export companies.

Available Forms:

Bayer’s injectable methenolone comes in 1 ml ampules containing 100 mg of methenolone. Other brands' compositions and dosages may vary depending on the country and manufacturer.

Structural Characteristics:

Methenolone is a derivative of dihydrotestosterone. It has an additional double bond between carbon atoms 1 and 2, which helps stabilize the 3-keto group and increase the steroid's anabolic nature. An additional 1-methyl group helps prevent metabolic breakdown in the liver. Methenolone is linked to a carboxylic acid ester at the 17β-hydroxyl group. Esterified steroids are less polar than free steroids and are absorbed more slowly at the injection site. Once in the bloodstream, the ester is removed to yield free (active) methenolone. Esterified steroids extend the therapeutic effect after administration, allowing for less frequent injections compared to unesterified steroids.

Side Effects (Estrogenic):

Methenolone does not aromatize in the body, and no estrogenic activity has been detected. Thus, there are no estrogenic side effects associated with its use. Those with a sensitive constitution also need not worry about gynecomastia or water retention. Methenolone can significantly increase muscle mass but not the smooth, voluminous type produced by aromatizable steroids.

Side Effects (Androgenic):

Although classified as an anabolic steroid, methenolone can still produce androgenic side effects. Common side effects may include oily skin, acne, and body/facial hair growth, especially at higher doses. Anabolic/androgenic steroids can also accelerate male pattern baldness. Female users should be aware of potential side effects, including voice deepening, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. While methenolone is a mild steroid, high doses can still produce significant androgenic effects. It is generally well-tolerated by women due to its relative mildness and effectiveness.

Side Effects (Hepatotoxicity):

Methenolone is considered non-hepatotoxic; thus, liver toxicity is unlikely to occur. Studies have not found significant changes in liver stress markers when using methenolone.

Side Effects (Cardiovascular):

As an anabolic/androgenic steroid, methenolone may adversely affect serum cholesterol. This includes lowering HDL (good) cholesterol and increasing LDL (bad) cholesterol levels, potentially leading to a greater risk of arteriosclerosis. The impact of anabolic/androgenic steroids on serum lipids depends on the dose, method of administration (oral or injectable), type of steroid (aromatizable or non-aromatizable), and resistance to hepatic metabolism. Methenolone has a stronger resistance to hepatic metabolism of cholesterol due to its non-aromatizable nature but is weaker than C-17α alkylated steroids. Due to its administration route, oral methenolone can have a more detrimental effect on blood lipids than injectable forms. Anabolic/androgenic steroids can also affect blood pressure and triglycerides, reduce subcutaneous relaxation, and cause left ventricular hypertrophy, all of which may increase the risk of cardiovascular disease and myocardial infarction.

To help reduce cardiovascular strain, it is recommended to maintain an active cardiovascular exercise regimen and always minimize the intake of saturated fats, cholesterol, and simple carbohydrates during active AAS administration. Supplementing with fish oil (4 grams per day) and natural cholesterol/antioxidant formulations like Lipid Stabil or similar ingredients is advised.

Side Effects (Testosterone Suppression):

Adequate doses of anabolic/androgenic steroids can effectively promote muscle growth while suppressing testosterone secretion. Without intervention involving testosterone-stimulating substances, testosterone levels are expected to normalize within 1-4 months after cessation of use. Note that drug abuse may lead to hypogonadism, requiring medical intervention. At moderate doses of 100-200 mg/week, methenolone's effect on testosterone suppression is significantly weaker than that of nandrolone, and due to its non-aromatizable nature, the hormonal recovery period should not be overly prolonged.

Treatment Guidelines (Male):

Prescription guidelines recommend starting treatment with a maximum injected dose of 200 mg, followed by a maintenance dose of 100 mg/week. For long-term use, generally, 100 mg is injected every two weeks, or 200 mg every 2-3 weeks. For male athletes, 200-400 mg per week for 6-12 weeks is sufficient to significantly increase lean muscle mass. However, doses of 600 mg/week or higher are not recommended, as they could exacerbate side effects on blood lipids, despite a stronger potency.

Methenolone works faster and stronger when combined with other steroids. During dieting or definition phases, it is often based with other non-aromatizable steroids like fluoxymesterone and drostanolone for a more potent effect on muscle hardness and density. Alternatively, another mild steroid such as stanozolol can be added, which can boost effects without additional side effects. Methenolone can also be used in muscle bulking training with testosterone or boldenone, effectively enhancing muscle quality without significant hepatotoxicity.

Treatment Guidelines (Female):

Prescription guidelines do not provide a separate dosage for female users, but they indicate that pregnant women, or those planning to become pregnant, should not use methenolone. Female athletes generally achieve good results with doses of 50-100 mg. If both oral and injectable forms of methenolone are used concurrently, oral administration is usually prioritized because it can better control hormone levels in the blood. Additionally, some female users may also inject calusterone (25 mg twice a week) or oxandrolone (7.5-10 mg per day) for enhanced anabolic effects. Methenolone's androgenic activity may be dose-dependent and should be closely monitored. If opting for a combination of different steroids, it is best to start with lower doses of each compared to when used alone, as the combined effect on the individual may be unpredictable. Alternatively, starting with oral methenolone before choosing an injectable form is also a viable option.

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